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Barbituates Information A History Of Barbituates Barbituric acid (a combination of urea and malonic acid) the base material of barbituates, which itself does not affect the CNS, was first synthesized on December 4, 1863 by Adolph von Bayer (his pharmaceutical firm also discovered Aspirin, Heroin, and many other compounds). The date of the discovery was the feast day of Saint Barbara, so he named his discovery Barbara's urates in her honor. Because barbituric acid does not effect …

…for supplying or producing these drugs. Quitting See your doctor before quitting, after regular use, tolerance and psychological dependence are likely to develop in any sedative but the danger with barbiturates is that the amount needed to cause respiratory failure increases relatively little. Serious problems of physical dependency are unlikely, but withdrawal effects can include irritability, fainting, nervousness, nausea and convulsions. Sudden withdrawal from very high doses can even be fatal. Medical advice is essential.