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Osteogenisis Imperfecta (OI)- DEFINITION Osteogenisis imperfecta (OI) is “a rare genetic disorder of collagen synthesis associated with broad spectrum of musculoskeletal problems, most notably bowing and fractures of the extremities, muscle weakness, ligamentous laxity, and spinal deformities.” (Binder, 386). Other collagen-containing extraskeletal tissues, such as the sclerae, the teeth, and the heart valves are also affected to a variable degree. OI has a “common feature of bony fragility associated with defective formation of collagen by …

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