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Loneliness affects many of the characters, and Steinbeck seems to show that it is a natural and inevitable result of the kind of life they are forced to lead. The itinerant workers are caught in a trap of loneliness - they never stay in one place long enough to form permanent relationships. Even if such relationships existed, they would probably be destroyed by the demands of the itinerant life. Let's examine the lonely situation of …

…feelings are all channelled into aggressive behaviour which further isolates his wife and leads to the incident with Lennie where his hand is crushed. Crooks is another who is isolated because he is different. He copes with it by keeping a distance between himself and the other hands. When he does allow himself to be drawn into the dream of working on George and Lennie's dream farm, he is immediately shut out by George's anger.